A field is created by running an electrical current through a coiled wire (inductive coils) to generate low level electromagnetic fields in the body which penetrates both soft and hard body tissue around the target area to affect a variety of biological processes. This field stimulates the normal anti-inflammatory cascades by a series of chemical reactions which activates the Nitric Oxide Cycle. Nitric Oxide is known to be a key molecule in healing for both humans and animals. This compound is released when we are injured or exercising for the body to naturally repair itself. Increases in the production of Nitric Oxide to help speed up the healing process of soft and hard. By using the specific ratio of frequency to burst width, the Assisi Loop has been proven to be the most effective at delivering the amount of current that is similar to what is already used by the body.
According to Gaynor: ‘The targeted PEMF technologies do not themselves cause bone growth or tissue regeneration outside of the context of injured tissue. This characteristic is likely part of the reason that these technologies are not associated with any known side-effects nor adverse events when used within clinical guidelines and indications for use.’ Gaynor et al., 2018.
To delve further into the mechanism of action for PEMF and clinical evidence, this review by Gaynor (2018) gives excellent coverage of PEMF in human and veterinary medical fields. It explains how the targeted PEMF waveform results in very efficient delivery of electric field to tissues, ensuring beneficial clinical effects of reduced inflammation in soft tissues, with small doses of treatment. Gaynor et al., 2018
This randomized, placebo-controlled, prospective clinical trial found that using the Assisi Loop to treat dogs with spinal cord injuries due to acute intervertebral disc extrusions (IVDE) resulted in:
(Zidan et al., 2018). https://www.liebertpub.com/doi/abs/10.1089/neu.2017.5485
This double-blind, randomized, placebo-controlled clinical trial found that using the Assisi Loop to treat dogs suffering from intervertebral disk disease (IVDD) resulted in:
(Olby et al., 2019). https://doi.org/10.5326/JAAHA-MS-6798
PEMF devices have been approved by the U.S. Food and Drug Administration (FDA) to treat:
(Gaynor, 2018) https://www.sciencedirect.com/science/article/pii/S003452881830208X